Brain cancer has a new cure – combination of drugs

New Delhi: Scientists claim that combination of drugs can be helpful in curing brain cancer tumours.

Researchers at the Children's Hospital of Eastern Ontario (CHEO) in Canada found that a combination of drugs known as SMAC Mimetics and immune checkpoint inhibitors (ICIs) amplifies kill rates of cancer tumour cells in laboratory testing.

They also discovered a new mechanism by which the combination promotes long-term immunity against glioblastoma tumours.

 

The combination therapy also proved to be highly effective against breast cancer and multiple myeloma.

"These findings represent a significant evolution in our research and the field of immunotherapy," said Robert Korneluk, professor at the University of Ottawa in Canada.

"We are the first in the world to show the synergistic tumour-killing impact of combining SMAC Mimetics with immune checkpoint inhibitors for glioblastoma," said Korneluk.

"You could say it takes two to tango. We believe that it takes a combination strategy to impact cancer cure rates," he said.

In 2014, researchers discovered that combining SMAC Mimetics with immune stimulators or live virus therapies had a synergistic or amplified tumour-killing effect that was greater than either agent on its own.

The new study shows that SMAC Mimetics also have a powerful synergistic effect with ICIs, relatively new drugs that are showing great promise in the clinic.

SMAC Mimetics known as LCL161 and Birinapant were combined with ICI antibodies targeting PD-1 and CTLA-4 immune checkpoints.

(With PTI inputs)