In a first, Kochi doctors perform dual live-donor transplant on 20-month-old girl

Kochi: In a significant medical breakthrough and a first in the world, a dual live-donor transplant was performed on a 20-month-old girl, who weighs just seven kgs by doctors at a hospital in Kochi on Saturday.

The toddler got a new lease of life after the doctors performed a complex surgery where live-donor liver and kidney transplant took place simultaneously.

Mathew Jacob, Consultant Liver and Abdominal Multi-Organ Transplant Surgeon at Aster Medcity, Kochi, Kerala said,'This is the first time in the world that a dual live-donor liver and kidney transplant surgery has been performed in such a small child.'

Baby Parvathy was first diagnosed with a chronic kidney problem when she was just three months old. She had Primary Hyperoxaluria Type 1 -- a very rare condition wherein the deficiency of a liver enzyme called AGXT leads to abnormal spike in blood oxalate levels, which in turn causes permanent kidney damage.

The doctors were determined that the only treatment option for Parvathy was a combined liver and kidney transplantation.

The little girl was put on an intense nutritional rehabilitation programme to attain a pre-transplant weight of 10 kilograms, along with dialysis.

However, she stopped gaining weight due to multiple complications, which posed a major challenge for the surgery, as children less than 10 kilograms do not have adequate space to accept an adult kidney.

"The solution was to remove her damaged right kidney and use the space vacated by her liver to place the new kidney. The blood volume in her kidney too had to be increased using highly specialised perioperative anaesthetic techniques," Jacob said in a statement on Saturday.

Her father and grandmother were identified as the liver and kidney donors, respectively.

The 20-hour transplant procedure comprised of three simultaneous surgeries on the liver donor, kidney donor and the recipient.

Post surgery, Parvathy stayed for 51 days in the hospital and recovered well and started gaining weight, according to the doctors.

(With IANS inputs)