Even low air pollution level may cause heart disease

London: Regular exposure to even low levels of air pollution may cause changes to the heart similar to those in the early stages of heart failure, a study warns.

The researchers from the Queen Mary University of London in the UK studied data from around 4,000 participants in the UK.

"We saw significant changes in the heart, even at relatively low levels of air pollution exposure," said Nay Aung, who led the data analysis published in the journal Circulation.

Volunteers provided a range of personal information, including their lifestyles, health record, and details on where they have lived.

Heart MRI (magnetic resonance imaging) was used to measure the size, weight, and function of the participant's hearts at fixed times.

There was a clear association between those who lived near loud, busy roads, and were exposed to nitrogen dioxide (NO2) or PM2.5, small particles of air pollution and the development of larger right and left ventricles in the heart.

The ventricles are important pumping chambers in the heart and, although these participants were healthy and had no symptoms, similar heart remodeling is seen in the early stages of heart failure, researchers said.

Higher exposures to the pollutants were linked to more significant changes in the structure of the heart, they said.

For every one extra microgramme per cubic metre of PM2.5 and for every 10 extra microgrammes per cubic metre of NO2, the heart enlarges by about one percent, the study shows.

Globally, coronary heart disease and stroke account for approximately six in ten (58 percent) deaths related to outdoor air pollution, the researchers said.
This research could help explain exactly how and why air pollution affects the heart.

In the study, average annual exposures to PM2.5 (8-12 microgramme per cubic metre) were well within UK guidelines (25 per cubic metre), although they were approaching or past World Health Organisation (WHO) guidelines (10 microgrammes per cubic metre).

"Air pollution should be seen as a modifiable risk factor. Doctors and the general public all need to be aware of their exposure when they think about their heart health, just like they think about their blood pressure, their cholesterol and their weight," said Aung.